As such, there’s no strong emotional core to what I’m watching. And if anything, it seems to me that those hallucinations would come to life and attack us physically the way they already afflict their victims mentally.īut unless KyoAni trolls the audience, the show seems destined for a very light-hearted feel. Like what, you ask? I mean, I don’t want to sit here and list all the atrocities that might just be happening right next door. After all, there’s no limit to human pain and suffering. If our hallucinations can come to life, then you would expect to see some fucked up shit, right? People who are going through some tough times would spawn phantoms that are unbelievably scary. So who’s to say that the ugly wall isn’t just the same thing but in a more subtler way that makes the audience question whether or not it’s a mistake on KyoAni’s part?īut crucially, I’m still bored. They say phantoms are hallucinations from the brain, and it would kinda make sense that for these young kids, video games or anything that references them would be on the brain. But there’s a layer of artificiality in the setting of Musaigen no Phantom World. People often like to take the simplest explanation, and leave it at that. But is this really an oversight by a studio like KyoAni? Who knows. It looks even worse in motion it looks like something out of a video game. We made sure to keep that the same.Īnd check out the wall next to the main character in this screenshot: It’s just that her name is Mai now, but don’t worry about her bust size. You want more Isuzu Sento? Have some more Isuzu Sento. Tonally, it feels more in line with some of their more fanservice-y, harem-y forays in recent history, so I’m kind of predisposed to disliking the show already. The bigger issue, rather, is that this is not one of KyoAni’s more ambitious projects. It depends on your point of view, I suppose. Is it a good thing or a bad thing to have a signature look to your anime? I dunno. One look at this girl, and you can just tell that this is a KyoAni production: It’s also interesting how easy it is to tell who does what. “For example,” the main character explains, “entities thought fictitious till now could appear before us in our reality.” Ah, hm, interesting. I just didn’t really care anymore, and the characters are too flat to keep my interest. It was at this point that the mystery lost its grip on me. The other protagonist, some cherubic-looking french horn player, insists on leaving the ominous musical notes up, because golly gee, Batman, it might be a cipher! But c’mon, just take a picture on your cell and move on. And the female protagonist really annoys me with her, “I want to be a girly girl now! Stop reminding me that I used to be a tomboy as a kid!” I’m sure these identity crises are commonplace among young teenagers, and they are just trying to find themselves in the turbulent years of high school, but it doesn’t interest me whatsoever. At this point, I was about to say “Next!” and move onto the next show, but then we have these bloody musical notes scrawled onto a blackboard? Who ever animated this pretty much dipped her in a bath of lacquer. Wow, that is one glossy-looking character. Oh damn it, it’s a show about yet another dying school club. Also, they throw in some half-parkour at the end of the first episode… and… and… and there’s always that cute female character who wants to be the club manager, because she just admires X, which is now running, and… I’m fucking bored already. Let me look in the thesaurus for a cool, sexy word. B…but wait, of all the sports clubs out there, X is the one he doesn’t want to join! Why not? Is it because of a painful past? GOD WHY CANT HE JUST ACCEPT HIS FATE?Īnyway, X this time happens to be running. The first episode is a retread of what I’m sure any typical anime viewer has probably seen countless of times before: X Club is all but forgotten, but a couple of our plucky protagonists can save it! Oh yes, they can! All they have to do is recruit that super talented dude who was no doubt born to do X. Let’s start off by taking a quick look at a few of them… This means I’ll have to pare down the list of this season’s shows by quite a bit. I really don’t want to bite off more than I can chew, so I’m aiming to blog maybe just 7 to 10 shows this season.
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If you choose to do business with this business, please let the business know that you contacted BBB for a BBB Business Profile.Īs a matter of policy, BBB does not endorse any product, service or business.SambaSafety and First Advantage announced that they have partnered to offer SambaSafety’s driver monitoring services for First Advantage’s transportation customers. BBB Business Profiles are subject to change at any time. When considering complaint information, please take into account the company's size and volume of transactions, and understand that the nature of complaints and a firm's responses to them are often more important than the number of complaints.īBB Business Profiles generally cover a three-year reporting period. However, BBB does not verify the accuracy of information provided by third parties, and does not guarantee the accuracy of any information in Business Profiles. BBB asks third parties who publish complaints, reviews and/or responses on this website to affirm that the information provided is accurate. Please fix it!īBB Business Profiles may not be reproduced for sales or promotional purposes.īBB Business Profiles are provided solely to assist you in exercising your own best judgment. Did anyone bother to read it?Yet almost every month, my Lyft driving account is literally being deactivated because my driver's license is supposedly invalid according to the information Lyft received from you.How can that be? How can my driver's license be valid one month, invalid the next, valid again the next, invalid again the following month, valid again? Do you see the insanity of this pattern? Doesn't that send a red flag that there's an error being made at SafetySamba. I was literally standing in the ******** DMV office which shows my driver's license is valid! I even sent you a copy. 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Some suggested that the White House pushed NASA to launch the shuttle in time for President Ronald Reagan’s State of the Union address But the cabin hit the water’s surface (at more than 200 mph) a full 2 minutes and 45 seconds after the shuttle broke apart, and it’s unknown whether any of the crew could have regained consciousness in the final few seconds of the fall. It’s likely that the Challenger’s crew survived the initial breakup of the shuttle but lost consciousness due to loss of cabin pressure and probably died due to oxygen deficiency pretty quickly. The pieces-including the crew cabin-reached an altitude of some 65,000 feet before falling out of the sky into the Atlantic Ocean below. Without its fuel tank and boosters beneath it, however, powerful aerodynamic forces soon pulled the orbiter apart. The fuel tank itself collapsed and tore apart, and the resulting flood of liquid oxygen and hydrogen created the huge fireball believed by many to be an explosion.Īfter the collapse of its fuel tank, the Challenger itself remained momentarily intact and actually continued moving upwards. The astronauts aboard the shuttle didn’t die instantly.Ī seal in the shuttle’s right solid-fuel rocket booster designed to prevent leaks from the fuel tank during liftoff weakened in the frigid temperatures and failed, and hot gas began pouring through the leak. Delta Sigma Pi is a professional fraternity organized in 1907 at NYU's School of Commerce, Accounts, and Finance to foster the study of business in universities to encourage scholarship, social activity and the association of students for their mutual advancement by research and practice to promote closer. Delta Sigma Pi is one of the largest co-ed professional business fraternities in the nation and has over 300 active chapters and over 250,000 initiated members. Welcome to official page for the Pi Rho Chapter of Delta Sigma Pi at UMass Amherst. Additionally, grants may be provided to cover costs associated with chapters or chapter members sponsoring or attending educational or professional/personal development speakers and/or workshops, conferences or similar events (including field trips to businesses that include significant elements of educational presentations, tours, etc. Delta Sigma Pi - Upsilon Psi Chapter Est. The Omicron chapter of Delta Sigma Pi is committed to instilling leadership, promoting diversity, tackling adversity, and achieving success. Delta Sigma Pi - Pi Rho, UMass Amherst, Amherst, Massachusetts. Chapters can request grants to defray the direct cost of LEAD Provincial Conferences, LEAD Schools, Grand Chapter Congress and Presidents' Academy. The Leadership Foundation established a CLF for each Delta Sigma Pi chapter. Delta-sigma ( or sigma-delta, ) modulation is a method for encoding analog signals into digital signals as found in an analog-to-digital converter (ADC). CLFs are chapter-specific accounts within the Delta Sigma Pi Leadership Foundation created to receive charitable gifts restricted to a chapter. R20-53: To allow Delta Sigma Pi’s Deltasig Career Achievement Award to be awarded annually, instead of biennially as is current policy. Today, coast to coast, more than 300 chapters and over 226,000 members support the goals and ideals of the Fraternity.įor more about Delta Sigma Pi at Xavier University, please click here.Ĭhapter Leadership Funds (CLFs) assure collegians always have access to Delta Sigma Pi's full array of educational programs. Delta Sigma Pi is a professional fraternity organized to foster the study of business in universities to encourage scholarship, social activity and the association of students for their mutual advancement by research and practice to promote closer affiliation between the commercial world and students of commerce, and to further a higher standard of commercial ethics and culture and the civic and commercial welfare of the community.ĭelta Sigma Pi was founded in 1907 at New York University: School of Commerce, Accounts and Finance by Harold Valentine Jacobs, Alexander Frank Makay, Alfred Moysello and Henry Albert Tienken. Further, differences in organ-/cell-specific septic proteotypes suggest that treatments could exert non-uniform effects across organs. Strategies that objectively quantify intervention efficacy at a molecular level and define on-/off-target intervention-specific effects are needed. Understanding molecular treatment responses introduced by tested interventions in models is limited by readouts like survival and inflammatory markers that offer little insight into organ dysfunction. Over the last four decades, >120 sepsis treatment trials have been conducted unsuccessfully despite promising results in preclinical models. Defining organotypic proteotypes in murine sepsis models, where each organ displays uniquely enriched protein signatures, can improve not only understanding of organ-specific combinations of damage, inflammation, and immunological and metabolic disease trajectories, but also assessment of treatment impact. Proteomics can provide valuable insights into time-resolved systems-wide and organ-/cell-specific septic proteotypes, i.e., proteome assessment at a particular time across organs 17, 18, 19, 20, 21, 22, 23, 24. However, knowledge of variations in organ responses due to differences in organ structure and function is limited. Sepsis-induced organ alterations are interconnected and systems-wide 16. Exact mechanisms of this dysfunction have not been elucidated, hindering development of novel mitochondria resuscitating drugs as adjuvant therapies. Loss of mitochondrial homeostasis and related bioenergetic disturbances may explain cessation of cellular functions without excessive cell death 14, 15. In this regard, metabolic deregulation due to aberrant mitochondrial pathways is an important process driving septic organ dysfunction 11, 12, 13. The systemic nature of sepsis introduces a highly complex pattern of overlapping molecular disease trajectories that can cause organ damage through disparate immunological and metabolic processes 9, 10. The variability in sepsis complicates delineation of patient subgroups/subphenotypes with similar clinical and molecular features 5, 6, 7, 8, which makes it challenging to introduce precision medicine strategies. Recent Sepsis-3 guidelines define the syndrome as life-threatening organ dysfunction caused by dysregulated host response to infection 4. Sepsis, a leading cause of mortality in ICUs 1, 2, contributes up to ~19% of deaths worldwide 3. We provide a strategy for the quantitative and organotypic assessment of treatment effects of candidate therapies in relationship to dosing, timing, and potential synergistic intervention combinations during sepsis. Mem introduced sepsis-independent perturbations in the mitochondrial proteome that Gcc counteracted. Gcc enhanced some positive proteome responses of Mem, including superior reduction of the inflammatory response in kidneys and partial restoration of sepsis-induced metabolic dysfunction. Three distinct proteome response patterns were identified, which depended on the underlying proteotype for each organ. Here, we used pharmacoproteomics to score time-dependent treatment impact in a murine Escherichia coli sepsis model after administering beta-lactam antibiotic meropenem (Mem) and/or the immunomodulatory glucocorticoid methylprednisolone (Gcc). This knowledge gap has resulted in ineffective biomarker development and suboptimal treatment regimens to prevent and manage organ dysfunction/damage. Sepsis is the major cause of mortality across intensive care units globally, yet details of accompanying pathological molecular events remain unclear. His solo track “Confession” is dripping with heartache. This was the perfect opportunity for Changmin to prove himself more than just a competent translator. The group’s debut album as a duo was a noticeable tentative step into finding the group’s new voice. He’d already started learning guitar-an instrument none of the members really professed to have any tangible knowledge of, piano being their weapon of choice-so branching out on his own creatively was naturally the next step. When the fivesome became a duo, Changmin was given more room to explore his creative side. I’d hug your hardened heart tightly in my arms forever” We’ll carry this dream forever together with love and trust “Just like the star that doesn’t leave the dark night sky Changmin took creative license, transforming the song from a power ballad about love’s redemption through heartbreak into a song about holding strong to one’s lover, holding that love between them and warming it, blocking out the ice instead of letting it settle and crack the foundations of their connection. While the Japanese lyrics-penned by Suzuki Daisuke-speak of a harsh love, borne through suffering and an icy desire to ignore the natural impulse to love, Changmin’s translation is… softer, much like the difference between singing in the sharper cadence of Japanese and the smoother rounded contours of Korean. But Changmin’s translation of the ballad adds an emotional weight to the music that anchors it and creates a lasting impression. While he didn’t do a great deal of composition work while the group was still five, Changmin first tried his hand at songwriting on DBSK’s fourth and most successful album, Mirotic, when he penned the Korean lyrics for their classic “Love in the Ice.” As most people already know, the song is incredibly evocative, the vocal and musical compositions alone eliciting visceral reactions to all who listen to it. That hasn’t stopped Changmin from flexing his creative muscle and delivering some truly gorgeous K-pop balladry. However, what frustrates me is why the two remaining members of the group must still rely on SM’s production team to create all of their songs. Nevertheless, their creative endeavors have been well-documented and quite prolific. The former members of DBSK- Jaejoong, Yoochun, and Junsu-have proven their prowess with a pen and behind the sound board.įollowing the very public breakup of the quintet, the men of JYJ have created most of their music, with varying levels of success and audience acceptance. One thing that’s always impressed and frustrated me about DBSK, past and present, is the members’ abilities to compose and create their own music. |
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